"New methods of curing alcoholism are being developed even as the problem worsens among the ponies of our nation, and I personally recommend the Detox
Through the use of genetic engineering and Earthpony magic, we have created a benevolent mutualist organism which could live in a commensalist relationship with their equine host.
The Detox bugs are delivered into hosts via a pill containing an egg of the organism, which would then grow and mature inside the alcoholic hosts' small intestines. While they normally survive by feeding on equine waste products, they are modified such that they could metabolize alcohol, but would produce a pain-receptor stimulating toxin as a by-product, causing immense but ultimately non-lethal pain to the alcoholic host. By the time the organism lived out its limited natural lifespan, the host would had lost all incentive to ever drink another drop again.
The engineered organisms had been repeatedly tested to ensure the safety of ponies taking the treatment, and with no reproductive organs to speak of, they pose little risks of spreading as a potential pathogen.
Pavlov programmed a dog salivate with the sight of food. Detox would give alcoholic ponies an incentive to quit alcohol"
--- Berry Punch, former Alcoholic, first test subject of Detox and now head-spokespony for the new Detox Alcoholic Cure.